Nixey, Thomas E : rechercher sur Z-Library

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1

Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline

Whittington, Douglas A., Epstein, Linda F., Smith, Adrian L., DeMorin, Frenel F., Paras, Nick A., Huang, Qi, Petkus, Jeffrey K., Doherty, Elizabeth M., Nixey, Thomas, Kim, Joseph L.

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 2.11 MB

english, 2009

2

ChemInform Abstract: The One-Pot Solution Phase Preparation of Fused Tetrazole-ketopiperazines.

Thomas Nixey, Michael Kelly, Christopher Hulme

Journal:

Année:

2001

Fichier:

PDF, 26 KB

2001

3

ChemInform Abstract: Two-Step Solution-Phase Synthesis of Novel Quinoxalinones Utilizing a UDC (Ugi/de-Boc/cyclize) Strategy.

Thomas Nixey, Paul Tempest, Christophe Hulme

Journal:

Année:

2002

Fichier:

PDF, 30 KB

2002

4

Rapid Assembly of Molecular Diversity via Exploitation of Isocyanide-Based Multi-Component Reactions

Christopher Hulme, Thomas Nixey

Journal:

Année:

2004

Fichier:

PDF, 69 KB

2004

5

Library Generation via Postcondensation Modifications of Isocyanide-Based Multicomponent Reactions

Christopher Hulme, Hugues Bienayme, Thomas Nixey, Balan Chenera, Wyeth Jones, Paul Tempest, Adrian L. Smith

Journal:

Année:

2005

Fichier:

PDF, 8 KB

2005

6

The one-pot solution phase preparation of fused tetrazole-ketopiperazines

Thomas Nixey, Michael Kelly, Christopher Hulme

Journal:

Tetrahedron Letters

Année:

2000

Langue:

english

Fichier:

PDF, 105 KB

english, 2000

7

Intramolecular Diels-Alder reactions of 2H-thiopyrans

Dale E. Ward, Thomas E. Nixey

Journal:

Tetrahedron Letters

Année:

1993

Langue:

english

Fichier:

PDF, 304 KB

english, 1993

8

Two-step solution-phase synthesis of novel quinoxalinones utilizing a UDC (Ugi/de-Boc/cyclize) strategy

Thomas Nixey, Paul Tempest, Christopher Hulme

Journal:

Tetrahedron Letters

Année:

2002

Langue:

english

Fichier:

PDF, 119 KB

english, 2002

9

Short solution phase preparation of fused azepine-tetrazoles via a UDC (Ugi/de-Boc/cyclize) strategy

Thomas Nixey, Michael Kelly, David Semin, Christopher Hulme

Journal:

Tetrahedron Letters

Année:

2002

Langue:

english

Fichier:

PDF, 133 KB

english, 2002

10

Rapid generation of cis-constrained norstatine analogs using a TMSN3-modified Passerini MCC/N-capping strategy

Thomas Nixey, Christopher Hulme

Journal:

Tetrahedron Letters

Année:

2002

Langue:

english

Fichier:

PDF, 143 KB

english, 2002

11

One-pot microwave assisted preparation of pyrazoloquinazolinone libraries

Thomas E. Vasquez, Thomas Nixey, Balan Chenera, Vijay Gore, Michael D. Bartberger, Yaxiong Sun, Christopher Hulme

Journal:

Molecular Diversity

Année:

2003

Langue:

english

Fichier:

PDF, 91 KB

english, 2003

12

Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer

Hu, Essa, Ma, Ji, Biorn, Christopher, Lester-Zeiner, Dianna, Cho, Robert, Rumfelt, Shannon, Kunz, Roxanne K., Nixey, Thomas, Michelsen, Klaus, Miller, Silke, Shi, Jianxia, Wong, Jamie, Hill Della Pupp

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 2.75 MB

english, 2012

13

Fragment Based Drug Discovery: Practical Implementation Based on 19F NMR Spectroscopy

Jordan, John B., Poppe, Leszek, Xia, Xiaoyang, Cheng, Alan C., Sun, Yax, Michelsen, Klaus, Eastwood, Heather, Schnier, Paul D., Nixey, Thomas, Zhong, Wenge

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 2.74 MB

english, 2012

14

Novel Vanilloid Receptor-1 Antagonists: 1. Conformationally Restricted Analogues of trans -Cinnamides †

Norman, Mark H., Zhu, Jiawang, Fotsch, Christopher, Bo, Yunxin, Chen, Ning, Chakrabarti, Partha, Doherty, Elizabeth M., Gavva, Narender R., Nishimura, Nobuko, Nixey, Thomas, Ognyanov, Vassil I., Rzasa

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 484 KB

english, 2007

15

Novel Vanilloid Receptor-1 Antagonists: 2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate

Doherty, Elizabeth M., Fotsch, Christopher, Bannon, Anthony W., Bo, Yunxin, Chen, Ning, Dominguez, Celia, Falsey, James, Gavva, Narender R., Katon, Jodie, Nixey, Thomas, Ognyanov, Vassil I., Pettus, L

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 280 KB

english, 2007

16

Intramolecular Diels–Alder reactions of 2 H -thiopyran dienes

Ward, Dale E., Nixey, Thomas E., Gai, Yuanzhu, Hrapchak, Matthew J., Abaee, M. Saeed

Journal:

Canadian Journal of Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1996

17

Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer’s disease

Chen, Jian Jeffrey, Qian, Wenyuan, Biswas, Kaustav, Yuan, Chester, Amegadzie, Albert, Liu, Qingyian, Nixey, Thomas, Zhu, Joe, Ncube, Mqhele, Rzasa, Robert M., Chavez, Frank, Chen, Ning, DeMorin, Frene

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 4.80 MB

english, 2013

18

The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors

Wurz, Ryan P., Pettus, Liping H., Jackson, Claire, Wu, Bin, Wang, Hui-Ling, Herberich, Brad, Cee, Victor, Lanman, Brian A., Reed, Anthony B., Chavez, Frank, Nixey, Thomas, Laszlo, Jimmy, Wang, Paul, N

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 934 KB

english, 2015

19

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors

Wu, Bin, Wang, Hui-Ling, Cee, Victor J., Lanman, Brian A., Nixey, Thomas, Pettus, Liping, Reed, Anthony B., Wurz, Ryan P., Guerrero, Nadia, Sastri, Christine, Winston, Jeff, Lipford, J. Russell, Lee,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 616 KB

english, 2015

20

Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates

Biswas, Kaustav, Nixey, Thomas E, Murray, Justin K., Falsey, James R, Yin, Li, Liu, Hantao, Gingras, Jacinthe, Hall, Brian E., Herberich, Brad, Holder, Jerry Ryan, Li, Hongyan, Ligutti, Joseph, Lin, M

Journal:

ACS Chemical Biology

Année:

2017

Langue:

english

Fichier:

PDF, 1.84 MB

english, 2017

21

Structure-guided Discovery of Dual-recognition Chemibodies

Cheng, Alan C., Doherty, Elizabeth M., Johnstone, Sheree, DiMauro, Erin F., Dao, Jennifer, Luthra, Abhinav, Ye, Jay, Tang, Jie, Nixey, Thomas, Min, Xiaoshan, Tagari, Philip, Miranda, Les P., Wang, Zhu

Journal:

Scientific Reports

Année:

2018

Langue:

english

Fichier:

PDF, 1.71 MB

english, 2018